The longer that overfed-mice stayed obese, the less likely correction of their diet and activity had long-term success in normalizing weight
Joint research between the University of Michigan and the Argentina-based National Council of Science and Technology (CONICET) has shed light on one of the most frustrating mysteries of weight loss – why the weight inevitably comes back.
A novel animal model showed that the longer mice remained overweight, the more “irreversible” obesity became, according to the new study that appeared online ahead of print Oct.24 in the Journal of Clinical Investigation.
Obesity affects more than 500 million adults and 43 million children younger than age 5, while related illnesses are the leading preventable cause of death.
Individuals who are overweight have a much higher risk of type 2 diabetes, hypertension, and cardiovascular diseases.